This general correspondence file offers extensive documentation on Nelson Rockefeller's business, civic, governmental, philanthropic, cultural, and social activities. Major files cover Dartmouth College's Committee on Economic Development, the Council for Inter-American Cooperation, the Council on Foreign Relations, the Institute for International Social Research, the Metropolitan Museum of Art, the Museum of Modern Art (MoMA), the Museum of Primitive Art (MoPA) founded by Rockefeller, the Whitney Museum of American Art, the Pan-American Union (Organization of the American States), Rockefeller Center, the United Jewish Appeal, the United Nations, the U.S. government, the Victory Clothing Drive for Overseas Relief, and the Westchester County Board of Health.

The Cultural Interests series reflects the Rockefeller family's involvement and contributions in the areas of the arts, museums, parks, and historic restorations. The series contains correspondence between members of the Rockefeller family and the Family Office Staff on the one hand, and officials and members of the various institutions and organizations on the other. Most of the material concerns unsolicited appeals for donations. Some members of the family were also members of or were active in several of the organizations, and some of the correspondence reflects this activity.