The collection of George Eastman's correspondence consists of over 700 letters. The first letter by him is dated November 20, 1864 and the last March 11, 1932. A little over half of the letters are personal ones to his mother and niece. Occasionally there are references in these letters to business affairs, especially in the early letters to his mother. There is a sprinkling of business letters, both to Mr. Eastman and to others by him. The rest of the collection is made up of 75th (1929) and 77th (1931) birthday greetings (including ones in 1929 from President Herbert Hoover and Thomas A. Edison), and "thank you" letters from friends to whom he had sent copies of his book, Chronicles of an African Trip, published privately in 1927, and of his biography, George Eastman, by Carl W. Ackerman, which was published in 1930.

The collection consists of correspondence, business records, ledgers and account books, notebooks and diaries, and blue prints.

The first two boxes of the collection contain exhibits compiled by Francis Bellamy's son, David, in his effort to establish the authenticity of his father's claim. The following four boxes include correspondence about the pledge controversy, speeches and articles written by Francis Bellamy, along with news clippings and articles written both about Bellamy and the pledge. This collection is closely related to collection D.147, David Bellamy Papers, 1892-1980.

The Hastings Horticultural Papers provide insight into the business of setting up a nursery in Chicago, along with much information regarding the various types of trees and plants shipped westward from Rochester.

The collection includes a copybook and diaries of Elisha Fish (1770-1804), a copybook of Catharine G. Bills (1819), and miscellaneous items and correspondence of Mrs. Catharine Ann (Fish) Stebbins (1835-1915) who lived in Rochester and was active in the anti-slavery movement and secretary of the Western New York Anti-Slavery Society. Letters from the following have been indexed: Mrs. Sophia Eliza (Rochester) Child; William Lloyd Garrison; Benjamin Franklin Butler (1818-1893); Mrs. Catharine Ann (Fish) Stebbins.

The collection includes letters to Juliett Woodworth (Mrs. Henry Fellows, in 1865) of Penfield, from various members of the Woodworth and Mead families, particularly from Mayfield, Fulton Co., N.Y. and from Michigan. Letters written during the Civil War from William N. Woodworth of the 140th New York Volunteers and Silas W. Allen of the 4th Michigan Battery. Letters from James Moore of the 108th New York Volunteers to John Fellows, Penfield, concerning the Civil War and various personal financial matters. Letters to Henry Fellows (Jr.) concerning financial matters.

The Ethel Rogers Papers includes diaries and published writings, mostly on vocational guidance for girls.

The Ellwanger Family Papers includes the letters, diaries, scrapbooks, personal financial papers, etc. of George Ellwanger, his wife Cornelia (Brooks) Ellwanger, and his children and grandchildren. Box 3 contains correspondence to Helen and Margaret Ellwanger (daughters of Edward S. and Leah Cresswell Ellwanger) variously addressed to them individually and jointly. Their correspondents include: Gertrude Jekyll, Marianne Moore, Gertrude Herdle Moore, William Robinson, and Fletcher Steele. Letters from the following have been indexed: Patrick Barry, Algernon Sidney Crapsey, George Eastman, David Jayne Hill, Henry O'Rielly, Mrs. Caroline (Erickson) Perkins, and Charles Sprague Sargent.

The Ellwanger and Barry Papers includes the records of Ellwanger and Barry Nursery to 1918, including correspondence, order books, sketchbooks, stock record books, catalogs, price lists, inventories, and account books; records of Ellwanger and Barry Realty Company to 1963, including financial and legal papers, account books, payroll records, and blueprints for houses on the Ellwanger and Barry tract. Also business and personal correspondence, account books, and financial records of Patrick Barry, Charles P. and Julia Wald Barry, Bernard and Harriet Barry Liesching, and Arthur A. Barry, including much information about Rochester banks and civic organizations. Also family photographs and scrapbooks; memorabilia; diaries of Patrick Barry, 1857-72; and record of soldiers' bounties, 1862-1863.

The collection includes detailed and illustrated field notes of his geological expeditions in the years 1872-1874, a loose-leaved geological report, personal diaries 1867-1911, account books and miscellaneous notes, newspaper clippings, etc.