The collection consists of correspondence, business records, ledgers and account books, notebooks and diaries, and blue prints.

Boxes contain business and legal papers, including wills, deeds, mortgages, birth and marriage certificates; lists of books and family possessions brought from England; clippings; genealogical and biographical material; unpublished bits of writing of several members of the family; tintypes, photographs, framed portraits; books, postcard album, and other memorabilia. One box contains family correspondence.

There are 15 boxes in the Virginia Moscrip Papers: 2 boxes of correspondence dating from 1818 through 1962, 3 boxes of Charles H. Moscrip ephemera reflecting his theological and theatrical interests as well as his time spent at the University of Rochester; 2 boxes of Virginia Moscrip ephemera from childhood through her years as a student and educator; 2 boxes of miscellaneous family ephemera; and 4 boxes of photo albums. Much of the family ephemera and correspondence are associated with Minerva (Lamareau) DeLany (1837-1919) and her husband, Amos N. DeLany (1832-1895), Virginia Moscrip's maternal grandparents, who had lived in Clyde, New York, since 1852. The DeLany's are buried in Mount Hope Cemetery in Rochester, New York, along with their grandchildren, Lydia Bell Moscrip, Minerva L. Moscrip, and Charles B. Moscrip and his wife, Elsie (1890-1912). The personal papers of Virginia Moscrip's mother, Lydia Bell DeLany Moscrip, are held at Smith College, Northampton, Massachusetts. Also included are Liberty Loan flyers and advertisements, membership cards and a service flag, food rationting campaign items and recipes, knitting patterns, two undated clippings, including an editorial by Anna Howard Shaw; and a commemorative booklet celebrating Susan B. Anthony's eightieth birthday.