The collection consiste of correspondence, memoranda, reports, bulletins, clippings, photographs, awards, and printed material. The files, arranged by genre and topic and reflect her philanthropic and legislative work in the areas of health, specifically cancer, heart disease, and mental health. Her civic and legislative work is covered in detail, as well as her private interests and activities.

Correspondence, memoranda, photographs, manuscripts, lists, legal and financial documents, and printed materials of Simon. The personal and business papers include correspondence with authors, inscribed photographs of authors, editorial files, files for his special art, photography, and music projects, correspondence files relating to Simon and Schuster, Inc., personal and family correspondence, documents, and photographs. Correspondents include Irving Berlin, Margaret Bourke-White, Henri Cartier-Bresson, Joseph E. Davies, Dwight D. Eisenhower, Philippe Halsman, Jerome Kern, Cole Porter, Kenneth Roberts, Arthur Schnitzler, Jerome Weidman, and Sloan Wilson.

The V. K. Wellington Koo papers document the diplomatic legacy of Wellington Koo as a Chinese statesman and diplomat of the 20th Century. The papers primarily consist of materials collected during Koo's diplomatic career, relating to the Lytton Commission, 1932-1933; the League of Nations, 1931-1940; the United Nations, 1944-1946; his ambassadorships to France, 1932-1941; to Britain, 1941-1946; to the United States, 1946-1956; as the Senior Advisor to the Republic of China from 1956; and as the Judge on the International Court of Justice, 1957-1966. The materials include correspondence, diaries, memoranda, manuscripts, documents, notes, speeches, maps, photographs, printed material, and audio visual material. The bulk of the materials emphasizes China's domestic and foreign affairs, such as the Sino-Japanese conflict, World War II and the Cold War in the Far East region, as well as the League of Nations and the United Nations.