The LaGuardia Memorial House Records document the settlement's activities from its earliest years as "The Home Garden" to its current social service programs for the youth of East Harlem. They offer a unique view of the first wave of the settlement movement in America, and document social conditions, demographic change, political activity, philanthropy and social work in East Harlem over a 90 year period. The records include: annual reports, board minutes and correspondence, headworker correspondence, financial records, fundraising information, and photographs.

The Union Settlement Association Records document a century of the settlement's activities, and provide a unique view of the first wave of the settlement movement in America. They document social conditions, demographic change, political activity, philanthropy and social work in East Harlem with a strong emphasis on the urban renewal period of the 1950s and '60s. The records include: annual reports, board minutes and committee files, headworker and executive director files, program reports, community organization files, and visual materials such as photographs, maps and architectural drawings.