The collection consiste of correspondence, memoranda, reports, bulletins, clippings, photographs, awards, and printed material. The files, arranged by genre and topic and reflect her philanthropic and legislative work in the areas of health, specifically cancer, heart disease, and mental health. Her civic and legislative work is covered in detail, as well as her private interests and activities.

The collection includes the original manuscript of "Surrender on Demand", Mr. Fry's account of his wartime experiences, which was later rewritten for young readers as "Assignment Rescue" (New York, Four Winds Press, 1968). Among the correspondents represented in the collection are Marc Chagall, Jacques Lipchitz, Roger Baldwin, Norman Thomas, J. Edgar Hoover, and Herman Wouk. In addition to the material relating to the Emergency Relief Committee (later known as the International Rescue Committee), the collection includes correspondence and papers concerning Fry's work as a writer on foreign affairs as well as copies of his books.