Central Files is composed chiefly of correspondence sent and received between Columbia University administrators and other University officers, faculty, and trustees, as well as correspondence sent and received between University administrators and individuals and organizations from outside the university.

The materials that comprise the Historical Biographical Files have been collected and added to from a variety of sources over the years by current and previous staff. The files consist of materials related to people who have a connection to the University whether as student, alumni, administrator, faculty, staff, guest lecturer, or honorary degree recipient. Materials generally consist of newspaper and magazine clippings, press releases, programs, ephemera, printed matter, lists, reports, and pamphlets.

The Morningside Area Alliance is an organization working for community improvement on behalf of its member institutions in the Morningside Heights neighborhood in New York City. The organization was founded as Morningside Heights Inc. in 1947 through joint action of fourteen Morningside Institutions--Columbia University, St. Luke's Hospital, Cathedral Church of St. John the Divine, Teacher's College, Barnard College, Corpus Christi Church, Home for Old Men and Aged Couples, International House, Jewish Theological Seminary, Juilliard School of Music, St. Hilda's and St. Hugh's School, The Riverside Church, Union Theological Seminary, and the Women's Hospital of St. Luke's Center--with the expressed purpose of "[promoting] the improvement of Morningside Heights as an attractive, residential, educational, and cultural area." The collection includes much, if not all, of the material that was created by the organization as part of its daily business from 1947 to 1992, when the materials were accessioned into University Archives at Columbia University. This includes records of the Board of Directors and the various Committees within the Alliance; assorted publications, reports, pamphlets, and theses both acquired and created by the organization; files of the different offices within the organization; maps, plans, and photographs used and created by the Alliance for its work; and the collected materials and files created for the organization's projects in different subject areas--specifically buildings, community services and programs, public safety, schools, and the Morningside General Neighborhood Renewal Plan. The collection also includes a large quantity of material rearranged into subject files on different areas of concern within the organization.

The V. K. Wellington Koo papers document the diplomatic legacy of Wellington Koo as a Chinese statesman and diplomat of the 20th Century. The papers primarily consist of materials collected during Koo's diplomatic career, relating to the Lytton Commission, 1932-1933; the League of Nations, 1931-1940; the United Nations, 1944-1946; his ambassadorships to France, 1932-1941; to Britain, 1941-1946; to the United States, 1946-1956; as the Senior Advisor to the Republic of China from 1956; and as the Judge on the International Court of Justice, 1957-1966. The materials include correspondence, diaries, memoranda, manuscripts, documents, notes, speeches, maps, photographs, printed material, and audio visual material. The bulk of the materials emphasizes China's domestic and foreign affairs, such as the Sino-Japanese conflict, World War II and the Cold War in the Far East region, as well as the League of Nations and the United Nations.