Edward Hicks Hume was a Protestant medical missionary in China and the founder of the Yale-Hunan Medical College. The collection contains monographs, a memorial pamphet for son T.C. Hume, correspondence and notes regarding T. C. Hume's appointment to a World Council of Churches post in Stockholm, a book list, and Chinese paper coins.

The collection consists of correspondence and materials relating to Ginling College including addresses, bulletins, reports, newsletters and conferences, as well as maps of Nanjing and glass lantern slides of missionary work.