The materials that comprise the Historical Biographical Files have been collected and added to from a variety of sources over the years by current and previous staff. The files consist of materials related to people who have a connection to the University whether as student, alumni, administrator, faculty, staff, guest lecturer, or honorary degree recipient. Materials generally consist of newspaper and magazine clippings, press releases, programs, ephemera, printed matter, lists, reports, and pamphlets.

The Alumni Class Records contains materials pertaining to the alumni from the Classes of 1842 to 1963, from Columbia College and the School of Mines, later the School of Engineering and Applied Sciences. Content includes programs, menus, invitations, clippings, correspondence, and printed matter related to activities from college days to the many reunion events in the subsequent years.

The Historical Subject Files Collection documents Columbia University history and related topics from 1754 to the present. The collection includes articles, booklets, clippings, correspondence, memoranda, non-photographic images, notes, pamphlets, posters, press releases, programs and reports.