The Alumni Class Records contains materials pertaining to the alumni from the Classes of 1842 to 1963, from Columbia College and the School of Mines, later the School of Engineering and Applied Sciences. Content includes programs, menus, invitations, clippings, correspondence, and printed matter related to activities from college days to the many reunion events in the subsequent years.

This collection includes floor plans, maps, correspondence, reports and press clippings pertaining to Columbia University campuses and buildings. The bulk of the collection is divided by building name; general maps, reports and correspondence relating to the Morningside Heights campus are filed separately.

This collection contains correspondence, newspaper clippings, calendars, posters and other printed matter, memorabilia including textiles, such as banners and t-shirts that document and commemorate the anniversary celebrations of Columbia University.

The materials that comprise the Historical Biographical Files have been collected and added to from a variety of sources over the years by current and previous staff. The files consist of materials related to people who have a connection to the University whether as student, alumni, administrator, faculty, staff, guest lecturer, or honorary degree recipient. Materials generally consist of newspaper and magazine clippings, press releases, programs, ephemera, printed matter, lists, reports, and pamphlets.

The Historical Subject Files Collection documents Columbia University history and related topics from 1754 to the present. The collection includes articles, booklets, clippings, correspondence, memoranda, non-photographic images, notes, pamphlets, posters, press releases, programs and reports.

The Strickman Cigarette Filter Collection documents Columbia's brief ownership of the patent for a cigarette filter invented by chemist Robert Strickman. Soon after their announcement of the agreement, the filter was found to be not much more effective than those in use at the time and Columbia withdrew its support. These records includes Columbia's statements, correspondence, and other materials generated throughout the incident.

The student strikes of this era, in particular that of 1968, represent the main focus of the collection, although other issues and many voices are expressed. The collection contains material authored by Columbia University administration, faculty, students, as well as non-affiliated organizations and individuals.