The materials that comprise the Historical Biographical Files have been collected and added to from a variety of sources over the years by current and previous staff. The files consist of materials related to people who have a connection to the University whether as student, alumni, administrator, faculty, staff, guest lecturer, or honorary degree recipient. Materials generally consist of newspaper and magazine clippings, press releases, programs, ephemera, printed matter, lists, reports, and pamphlets.

The Strickman Cigarette Filter Collection documents Columbia's brief ownership of the patent for a cigarette filter invented by chemist Robert Strickman. Soon after their announcement of the agreement, the filter was found to be not much more effective than those in use at the time and Columbia withdrew its support. These records includes Columbia's statements, correspondence, and other materials generated throughout the incident.