The collection consists of original home recordings on wax cylinders intentionally done by Dr. Albert Leffingwell to preserve some family memories. Voices of three generations of family members are recorded.

Letter from civil engineer Anthony Walton White Evans, describing his work surveying the "damnable" 30,000 acres of Montezuma and Cayuga swamps in central New York for the Erie Canal.

Printed material relating to the ballooning exploits of Carl E. and Mary "Carlotta" Myers.

Medical receipts of Hill's general practice in Syracuse, New York

Medical account book recording details of Dr. Merrick's practice, patients, and personal life. Dr. Merrick lived and practiced in Longmeadow, Massachusetts; Franklin, Connecticut; and Lebanon, New York (Madison County).

Daybook recording activities of physician in 19th century Geddes, New York.

Records of Fairfield Academy and Fairfield Medical College, Herkimer County, New York, and the personal papers of Dr. William Mather, Alonzo C. Mather, Albert B. Watkins, and other families and individuals connected with the school and town.

Detailed account and memoranda books of a Pulaski, New York manufacturer of orthopedic braces; in addition to financial data the books include daily notations on both business and personal activities and appointments, the weather, and current news and events.

Manuscript by George Edward Cragin, physician to the Oneida Community, on "Male Continence or Self Control in Sexual Intercourse: Its History and Its Practice"

World War II correspondence between Helen Stringer and her husband Sydney, a Captain in the U.S. Army Medical Corps, stationed in North Africa, Italy, France, and Germany.