Isaac Edwards (1819-1879) was born in South Corinth, New York. He married Anna (1826-1907), a granddaughter of Ezra Ames, and had three children who survived to adulthood. Isaac eventually became a professor at the Albany Law School, served on the Albany Board of Public Instruction, and became a member of the Congregational Church. This collection includes clippings, essays, photographs, and other Edwards family-related materials.

Morris Gerber was a typesetter at the Albany, NY newspaper, the Times-Union. The Morris Gerber Photograph Collection represents a significant documentation of the architectural, social, cultural and economic development of Albany's history from the 1860's into the 1970's.

The Pruyn Family Papers contains documents relating to three consecutive generations of the John Pruyn Family, along with genealogies and personal papers of more distant family relations. An autograph collection of presidents, statesmen, and local historic figures is included. The ownership of 43-45 North Pearl Street is documented from the first sale in 1679 to the last in 1968. The estates of Eleanor Erving, Justine Bayard Erving and Van Rensselaer Pruyn are also documented.

Thomas Worth Olcott (1795-1880) was born in Hudson, Columbia County, New York, to Josiah and Carolina Worth Olcott. Olcott eventually became president of the Mechanics and Farmer Bank in Albany, New York, and served on the boards of the Albany Law School and the Dudley Observatory, among others. This collection contains estate records, correspondence, newspaper clippings, bills, account books, photographs, scrapbooks, and genealogical information.