Alpha Tau Omega (ATO) installed its Epsilon Phi chapter at Syracuse University in 1950. Before becoming the 107th chapter of ATO, the fraternity was Sigma Beta, a local organization founded at Syracuse University in 1911.

Starting in 1922, when they were still Sigma Beta, the fraternity hosted a unique tradition at Syracuse University: the firing of the ATO cannon. The cannon was a gift from an alumnus and would be wheeled by four members of the fraternity to Archbold Stadium for home football games. For each touchdown, the cannon would be fired. Until its cease-fire in 1960, the ATO cannon was the oldest tradition at Syracuse not sponsored by the University.

In 1949 the fraternity moved into 748 Comstock and resided there until at least 1964. Between 1969 and 1974 the University experienced an extreme decline in Greek participation. During this time the Epsilon Phi chapter of Alpha Tau Omega folded.

In 1985 the ATO Epsilon Phi chapter became active once again. During this time the fraternity rented Sigma Alpha Epsilon’s old house on Marshall Street. In 1989 the Epsilon Phi chapter was awarded Alpha Tau Omega’s True Merit Chapter award and in 1990 the ATO house was the first of Syracuse’s fraternities to participate in the blue light safety house program.

In 2000 the chapter was suspended due to allegations of disorderly conduct off campus and was unrecognized as a fraternity by the University until 2005. The national organization of Alpha Tau Omega, however, continued to recognize the chapter's charter during this time. Due to this, the Epsilon Phi chapter became the first chapter to be independent of a University affiliation in the history of ATO. For the five year period the chapter continued to function as a normal fraternity off campus. In 2005 the chapter regained recognition from the University.

The Epsilon Phi chapter of ATO is currently located on 304 Walnut Place.